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Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.   Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Human genetics --- Neuropathology --- Human medicine --- medische genetica --- farmacologie --- geneeskunde --- hersenen --- genetica --- moleculaire biologie

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De genetica heeft voor de psychiatrie de laatste decennia een exponentieel grotere betekenis gekregen. De literatuur over dit domein groeit evenredig, maar wordt ook complexer. Van daaruit ontstond de behoefte aan een handboek dat een goede basis kan vormen om zich in te werken in dit onderzoeksveld. Dit boek brengt in ons taalgebied voor het eerst alle actuele ontwikkelingen in de psychiatrische genetica bij elkaar, niet alleen wat betreft de zoektocht naar oorzakelijke genetische mutaties, maar ook wat betreft interacties tussen genen en omgeving, en klinische implicaties van de genetica, zoals de farmacogenetica. Ook ethische aspecten van het omgaan met genetische gegevens komen aan bod.

600.2 --- 606.2 --- Genetica --- genetisch advies --- moleculaire genetica --- psychiatrische problemen --- farmacogenetica --- farmacologie --- ethiek --- Erfelijkheidsleer --- Psychiatrie; algemeen

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In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.

Genetics --- Histology. Cytology --- General biochemistry --- Biology --- genomen (geneeskunde) --- medische genetica --- proteomics --- biochemie --- biologie --- genetica --- cytologie --- histologie --- proteïnen

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Circadian rhythms are such an innate part of our lives that we rarely pause to speculate why they even exist. Perhaps this is the reason why in the medical practice the circadian variability of hormones, metabolites, physiological behaviors or the relevance of time in the presence or absence of different pathologies, have been practically ignored in the past. Some studies have suggested that the disruption of the circadian system may be cause for obesity and manifestations of Metabolic Syndrome (MetS). Shift-work, sleep-deprivation and bright-light-exposure at night are related to increased adiposity (obesity) and prevalence of MetS. Chronobiology and Obesity examines recent advances that have led to researchers to find the relevant link which exists between chronobiology and obesity, but, as it is emphasized throughout the book, there is much more that needs to be explored between the connection.

Human biochemistry --- Human genetics --- Pathological biochemistry --- Pathological endocrinology --- Human medicine --- medische biochemie --- obesitas --- medische genetica --- biochemie --- biomedische wetenschappen --- endocrinologie --- genetica

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The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly.

Biology --- Human biochemistry --- Human genetics --- Pathological biochemistry --- Human medicine --- Biotechnology --- medische biochemie --- medische genetica --- biochemie --- biologie --- biomedische wetenschappen --- genetica --- biotechnologie